Pac Epidem East London
Dayem Ullah
09/11/2020
Overall Cohort Characteristics
| Pan-Cancer (N=930) | HB-Cancer (N=1151) | Pan-disease (N=4409) | HB-disease (N=21002) | Control (N=5895) | Total (N=33387) | p value | |
|---|---|---|---|---|---|---|---|
| Gender | < 0.0011 | ||||||
| Â Â Â Female | 439 (47.2%) | 430 (37.4%) | 2043 (46.3%) | 11186 (53.3%) | 1681 (28.5%) | 15779 (47.3%) | |
| Â Â Â Male | 491 (52.8%) | 721 (62.6%) | 2366 (53.7%) | 9816 (46.7%) | 4214 (71.5%) | 17608 (52.7%) | |
| Ethnicity | < 0.0011 | ||||||
| Â Â Â White | 519 (66.6%) | 549 (53.7%) | 2370 (57.6%) | 10396 (51.5%) | 3280 (57.7%) | 17114 (53.9%) | |
| Â Â Â South Asian | 79 (10.1%) | 230 (22.5%) | 874 (21.2%) | 5207 (25.8%) | 942 (16.6%) | 7332 (23.1%) | |
| Â Â Â Black | 98 (12.6%) | 121 (11.8%) | 408 (9.9%) | 2046 (10.1%) | 806 (14.2%) | 3479 (10.9%) | |
| Â Â Â Far/South-east Asian | 4 (0.5%) | 24 (2.3%) | 19 (0.5%) | 234 (1.2%) | 31 (0.5%) | 312 (1.0%) | |
| Â Â Â Arab/North African | 0 (0.0%) | 0 (0.0%) | 1 (0.0%) | 15 (0.1%) | 5 (0.1%) | 21 (0.1%) | |
| Â Â Â Asian (Other) | 17 (2.2%) | 46 (4.5%) | 178 (4.3%) | 970 (4.8%) | 234 (4.1%) | 1445 (4.5%) | |
| Â Â Â Mixed | 9 (1.2%) | 8 (0.8%) | 49 (1.2%) | 241 (1.2%) | 78 (1.4%) | 385 (1.2%) | |
| Â Â Â Other | 53 (6.8%) | 45 (4.4%) | 217 (5.3%) | 1065 (5.3%) | 306 (5.4%) | 1686 (5.3%) | |
| Diagnosis age (years) | < 0.0012 | ||||||
| Â Â Â Mean (SD) | 66.91 (12.72) | 65.24 (13.22) | 52.90 (18.51) | 53.64 (17.67) | 54.77 (17.59) | 54.51 (17.77) | |
| Â Â Â Median | 67.21 | 66.06 | 51.28 | 52.42 | 54.09 | 53.62 | |
| Â Â Â Q1,Q3 | 58.88, 76.07 | 56.79, 75.15 | 38.36, 67.20 | 39.90, 66.40 | 41.02, 68.00 | 40.66, 67.85 | |
| Diagnosis age group | < 0.0011 | ||||||
| Â Â Â 18-40 | 27 (2.9%) | 54 (4.7%) | 1318 (29.9%) | 5663 (27.0%) | 1470 (24.9%) | 8532 (25.6%) | |
| Â Â Â 41-50 | 66 (7.1%) | 100 (8.7%) | 862 (19.6%) | 4149 (19.8%) | 1097 (18.6%) | 6274 (18.8%) | |
| Â Â Â 51-60 | 189 (20.3%) | 266 (23.1%) | 773 (17.5%) | 4186 (19.9%) | 1163 (19.7%) | 6577 (19.7%) | |
| Â Â Â 61-70 | 290 (31.2%) | 325 (28.2%) | 574 (13.0%) | 3022 (14.4%) | 961 (16.3%) | 5172 (15.5%) | |
| Â Â Â 71-80 | 234 (25.2%) | 273 (23.7%) | 519 (11.8%) | 2311 (11.0%) | 733 (12.4%) | 4070 (12.2%) | |
| Â Â Â >80 | 124 (13.3%) | 133 (11.6%) | 363 (8.2%) | 1671 (8.0%) | 471 (8.0%) | 2762 (8.3%) | |
| Mortality | < 0.0011 | ||||||
| Â Â Â Deceased | 754 (81.1%) | 795 (69.1%) | 840 (19.1%) | 3634 (17.3%) | 614 (10.4%) | 6637 (19.9%) | |
| Â Â Â Survived | 176 (18.9%) | 356 (30.9%) | 3569 (80.9%) | 17368 (82.7%) | 5281 (89.6%) | 26750 (80.1%) | |
| Survival (months) | < 0.0012 | ||||||
| Â Â Â Mean (SD) | 15.88 (24.91) | 22.37 (29.54) | 49.69 (64.39) | 58.03 (77.33) | 57.50 (71.17) | 54.43 (73.08) | |
| Â Â Â Median | 8.05 | 12.47 | 28.93 | 34.87 | 36.57 | 32.20 | |
| Â Â Â Q1,Q3 | 2.58, 18.18 | 3.52, 29.40 | 9.60, 66.17 | 12.50, 73.46 | 14.57, 71.95 | 11.07, 69.57 |
- Pearson’s Chi-squared test
- Kruskal-Wallis rank sum test
Risk analysis - HB-Cancer Vs Control - Black
Survival analysis
Baseline plots
Kaplan-Meier plots - HB-Cancer - Black
Demographics
Medical History
Lifestyle conditions
Hazard Ratio analysis - HB-Cancer - Black
